TABLE 3.

Effect of therapeutic treatment with minocycline on the macroscopic scores of colitis severity.

Parameter (%)	Edema	Erythema	Diarrhea	Blood in stool	Anorectal bleeding	Adhesion
UT	0	0	0	0	0	0
Vehicle	100 *	71 *	71 *	50*	100 *	85 *
10 mg/kg	100 *	0 #	71 *	0	57 *#	71 *
20 mg/kg	66 *#	0 #	50 *#	0	50 *#	66 *#
30 mg/kg	33 *#	0 #	50 *#	0	0 #	50 *#
40 mg/kg	0 #	0 #	0 #	0	0 #	0 #

Colitis severity was assessed in UT mice and mice treated with DSS for 4 days, followed by 3 days of daily i. p administration of minocycline or vehicle (PBS) (without DSS treatment) (n = 7 per group). * denotes a significant difference from UT mice; # denotes a significant difference from DSS/vehicle-treated mice.