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. 2023 Nov 16;14:1250203. doi: 10.3389/fendo.2023.1250203

Table 4.

Metabolic parameters of lipodystrophy syndromes at first visit.

Overall
(n=115)
Generalised lipodystrophy
(n=24)
Partial lipodystrophy
(n=91)
P value
Fasting glucose (mg/dL) 136.6 ± 83.7 136.5 ± 64.9 136.7 ± 89.5 0.557
HbA1c* (%) 7.9 ± 2.2 8.6 ± 2.6 7.7 ± 2.1 0.444
- HbA1c > 7%* n (%) 26 (52.0) 8 (72.7) 18 (46.1) 0.560
Insulin (mIU/L) 24.8 ± 24.8 38.8 ± 37.1 21.5 ± 19.8 0.067
HOMA-IR 9.6 ± 19.9 8.7 ± 7.9 9.9 ± 22.7 0.087
C-peptide (ng/mL) 2.8 ± 1.9 2.7 ± 1.9 2.8 ± 1.9 0.393
Total cholesterol (mg/dL) 180.9 ± 45.7 155.9 ± 46.3 188.7 ± 43.1 0.123
Non-HDL-C (mg/dL) 139.9 ± 45.5 123.0 ± 44.1 146.3 ± 44.9 0.290
LDL-C (mg/dL) 100.7 ± 38.5 71.8 ± 33.4 111.9 ± 34.5 0.002
HDL-C (mg/dL) 40.4 ± 16.2 32.2 ± 15.5 43.7 ± 15.5 0.014
Triglycerides (mg/dL) 152.0 (47.0-1937) 249.0 (55.0-1681.0) 142.5 (47.0-1937) 0.055
- Triglycerides >150 mg/dL n (%) 54 (46.9) 13 (54.2) 41 (45.0) 0.382
- Triglycerides >500 mg/dL n (%) 12 (10.4) 7 (29.2) 5 (5.5) 0.011
GGT (IU/L) 19 (6.0-583.0) 21.0 (12.0-147.0) 19.0 (6.0-583.0) 0.869
AST (IU/L) 23.3 ± 13.9 27.4 ± 17.4 22.2 ± 12.9 0.674
ALT (IU/L) 20.0 (5.0-98.0) 32.5 (6.0-186.0) 23.5 (5.0-132.0) 0.158
Urea (mg/dL) 34.4 ± 15.5 29.7 ± 20.4 35.8 ± 13.7 0.888
Creatinine (mg/dL) 0.7 ± 0.7 0.5 ± 0.4 0.8 ± 0.7 0.724
CK (IU/L) 93 (34.0-916.0) 110.5 (45.0-916.0) 93.0 (34.0-331.0) 0.322
Leptin** (μg/L) 0.3 (0.1-47.0) 0.3 (0.1-0.9) 4.3 (0.1-47.0) <0.0001

Data are mean ± SD or median (IQR) values and n (%) values. Subjects with progeroid syndrome, prepuberal subjects with familial partial lipodystrophy and patients with familial partial lipodystrophy and no data were excluded from this analysis. Age and gender were used as covariables. p < 0.05. *Among patients with diabetes. **Without or prior to leptin treatment. HbA1c, glycated haemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyl transpeptidase; CK, creatinine kinase.