Table 4.
Overall (n=115) |
Generalised lipodystrophy (n=24) |
Partial lipodystrophy (n=91) |
P value | |
---|---|---|---|---|
Fasting glucose (mg/dL) | 136.6 ± 83.7 | 136.5 ± 64.9 | 136.7 ± 89.5 | 0.557 |
HbA1c* (%) | 7.9 ± 2.2 | 8.6 ± 2.6 | 7.7 ± 2.1 | 0.444 |
- HbA1c > 7%* n (%) | 26 (52.0) | 8 (72.7) | 18 (46.1) | 0.560 |
Insulin (mIU/L) | 24.8 ± 24.8 | 38.8 ± 37.1 | 21.5 ± 19.8 | 0.067 |
HOMA-IR | 9.6 ± 19.9 | 8.7 ± 7.9 | 9.9 ± 22.7 | 0.087 |
C-peptide (ng/mL) | 2.8 ± 1.9 | 2.7 ± 1.9 | 2.8 ± 1.9 | 0.393 |
Total cholesterol (mg/dL) | 180.9 ± 45.7 | 155.9 ± 46.3 | 188.7 ± 43.1 | 0.123 |
Non-HDL-C (mg/dL) | 139.9 ± 45.5 | 123.0 ± 44.1 | 146.3 ± 44.9 | 0.290 |
LDL-C (mg/dL) | 100.7 ± 38.5 | 71.8 ± 33.4 | 111.9 ± 34.5 | 0.002† |
HDL-C (mg/dL) | 40.4 ± 16.2 | 32.2 ± 15.5 | 43.7 ± 15.5 | 0.014† |
Triglycerides (mg/dL) | 152.0 (47.0-1937) | 249.0 (55.0-1681.0) | 142.5 (47.0-1937) | 0.055 |
- Triglycerides >150 mg/dL n (%) | 54 (46.9) | 13 (54.2) | 41 (45.0) | 0.382 |
- Triglycerides >500 mg/dL n (%) | 12 (10.4) | 7 (29.2) | 5 (5.5) | 0.011† |
GGT (IU/L) | 19 (6.0-583.0) | 21.0 (12.0-147.0) | 19.0 (6.0-583.0) | 0.869 |
AST (IU/L) | 23.3 ± 13.9 | 27.4 ± 17.4 | 22.2 ± 12.9 | 0.674 |
ALT (IU/L) | 20.0 (5.0-98.0) | 32.5 (6.0-186.0) | 23.5 (5.0-132.0) | 0.158 |
Urea (mg/dL) | 34.4 ± 15.5 | 29.7 ± 20.4 | 35.8 ± 13.7 | 0.888 |
Creatinine (mg/dL) | 0.7 ± 0.7 | 0.5 ± 0.4 | 0.8 ± 0.7 | 0.724 |
CK (IU/L) | 93 (34.0-916.0) | 110.5 (45.0-916.0) | 93.0 (34.0-331.0) | 0.322 |
Leptin** (μg/L) | 0.3 (0.1-47.0) | 0.3 (0.1-0.9) | 4.3 (0.1-47.0) | <0.0001† |
Data are mean ± SD or median (IQR) values and n (%) values. Subjects with progeroid syndrome, prepuberal subjects with familial partial lipodystrophy and patients with familial partial lipodystrophy and no data were excluded from this analysis. Age and gender were used as covariables. †p < 0.05. *Among patients with diabetes. **Without or prior to leptin treatment. HbA1c, glycated haemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyl transpeptidase; CK, creatinine kinase.