Estimated metabolic activities such as GI absorption, permeation of blood–brain barrier (BBB), P-gp substrate, CYP1A2 inhibitor, CYP2C19, CYP2C9, CYP2D6, CYP3A4 and log K_p (cm s⁻¹) for the reference drugs Ref (1–4) and 12 groups of studied inhibitors using BOILED-Egg in the SwissADME webserver.

Complex	GI abs	BBB	P-gp subs	CYP1A2	CYP2C19	CYP2C9	CYP2D6	CYP3A4	log Kp (cm s−1)
Ref 1	High	Yes	No	Yes	Yes	Yes	Yes	Yes	−5.91
Ref 2	High	Yes	No	Yes	No	No	Yes	Yes	−4.96
Ref 3	High	No	No	No	No	No	No	No	−7.46
Ref 4	High	Yes	No	No	Yes	No	Yes	No	−6.43
1a	Low	No	No	No	No	Yes	No	Yes	−5.92
1b	Low	No	No	No	No	No	No	Yes	−5.92
2a	High	Yes	No	Yes	Yes	Yes	No	Yes	−5.29
2b	High	Yes	No	Yes	Yes	Yes	Yes	Yes	−5.02
3-1a	High	No	No	Yes	No	No	Yes	No	−5.45
3-1b	High	No	No	Yes	Yes	Yes	No	No	−5.21
3-2a	High	No	No	Yes	No	Yes	No	No	−5.45
3-2b	High	No	No	Yes	Yes	Yes	No	No	−5.33
3-3a	High	No	No	Yes	No	Yes	No	No	−5.75
3-3b	High	No	No	Yes	No	Yes	No	No	−5.52
3-4a	High	No	No	Yes	Yes	Yes	No	No	−5.46
3-4b	High	No	No	Yes	Yes	Yes	No	No	−5.23
4a	High	No	Yes	No	No	No	Yes	No	−5.02
4b	High	No	Yes	No	No	No	Yes	No	−5.01
4c	High	No	Yes	No	Yes	No	Yes	No	−4.77
5a	High	Yes	Yes	No	No	Yes	Yes	Yes	−5.43
5b	High	Yes	Yes	No	No	Yes	Yes	Yes	−5.35
6a	High	Yes	No	Yes	No	No	No	No	−6.04
6b	High	Yes	No	Yes	No	No	No	No	−5.78
7a	High	No	Yes	Yes	No	No	No	No	−6.07
7b	High	No	No	No	Yes	Yes	Yes	Yes	−6.50
8a	High	Yes	No	Yes	Yes	Yes	Yes	Yes	−4.90
8c	High	Yes	No	No	Yes	Yes	Yes	No	−4.43
9a	High	Yes	Yes	No	No	No	No	No	−7.18
9b	High	Yes	Yes	No	No	No	No	No	−7.18
9c	High	Yes	No	Yes	Yes	No	Yes	No	−6.47
10a	High	Yes	No	Yes	Yes	Yes	No	No	−4.94
10b	High	Yes	No	Yes	Yes	Yes	No	No	−4.94
10c	High	Yes	No	Yes	Yes	Yes	No	No	−4.46
11a	High	Yes	Yes	Yes	No	No	Yes	Yes	−5.84
11b	High	Yes	No	No	No	No	No	No	−5.61
11c	High	No	No	No	No	No	No	No	−5.37
12a	High	No	No	Yes	No	Yes	Yes	No	−5.59
12b	High	No	No	Yes	No	Yes	No	No	−5.56
12c	Low	No	No	Yes	No	Yes	No	No	−5.33