Table 4.
Univariate and multivariate analyses of DFS
| Characteristics | Events/N | Univariate analyses | Multivariate analyses | ||||
|---|---|---|---|---|---|---|---|
| HR | 95%CI | p | HR | 95%CI | p | ||
| Age | |||||||
| <= 60 years | 17/52 | - | - | - | - | - | - |
| > 60 years | 26/71 | 1.1 | 0.60 - 2.03 | 0.762 | - | - | - |
| Sex | |||||||
| Female | 3/17 | - | - | - | - | - | - |
| Male | 40/106 | 2.45 | 0.76 - 7.93 | 0.134 | - | - | - |
| Tumor size | |||||||
| <= 3 cm | 20/53 | - | - | - | - | - | - |
| >3 cm | 14/35 | 1.04 | 0.52 - 2.06 | 0.911 | - | - | - |
| Smoking | |||||||
| No | 7/38 | - | - | - | - | - | - |
| Yes | 36/85 | 2.66 | 1.18 - 5.97 | 0.018 | - | - | - |
| Alcohol drinking | |||||||
| No | 9/43 | - | - | - | - | - | - |
| Yes | 34/80 | 2.34 | 1.12 - 4.88 | 0.024 | 2.37 | 1.04-5.42 | 0.041 |
| Differentiation degree | |||||||
| Well-differentiated | 15/54 | - | - | - | - | - | - |
| Moderately differentiated | 15/40 | 1.23 | 0.60 - 2.52 | 0.567 | - | - | - |
| Poorly differentiated | 13/29 | 1.62 | 0.77 - 3.41 | 0.203 | - | - | - |
| Perineural invasion | |||||||
| No | 26/86 | - | - | - | - | - | - |
| Yes | 17/37 | 1.73 | 0.85 - 3.52 | 0.130 | - | - | - |
| Vascular invasion | |||||||
| No | 28/88 | - | - | - | - | - | - |
| Yes | 15/35 | 1.3 | 0.65 - 2.60 | 0.460 | - | - | - |
| Pre-operation FR+CTC (FU/3ml) | |||||||
| < 14.79 | 30/97 | - | - | - | - | - | - |
| >= 14.79 | 13/26 | 1.98 | 1.03 - 3.81 | 0.040 | 2.76 | 1.31-5.80 | 0.007 |
| Post-operation FR+CTC (FU/3ml) | |||||||
| < 17.42 | 9/44 | - | - | - | - | - | - |
| >= 17.42 | 4/6 | 5.92 | 1.74 - 20.13 | 0.004 | - | - | - |
| T | |||||||
| 0 | 6/18 | - | - | - | - | - | - |
| is | 0/2 | 0 | 0 - Inf | 0.996 | - | - | - |
| 1 | 6/20 | 0.81 | 0.26 - 2.53 | 0.721 | - | - | - |
| 2 | 3/16 | 0.53 | 0.13 - 2.13 | 0.375 | - | - | - |
| 3 | 26/57 | 1.5 | 0.62 - 3.65 | 0.371 | - | - | - |
| 4 | 1/2 | 2.79 | 0.33 - 23.3 | 0.343 | - | - | - |
| N | |||||||
| 0 | 17/49 | - | - | - | - | - | - |
| 1 | 16/44 | 1.1 | 0.56 - 2.19 | 0.776 | - | - | - |
| 2 | 6/19 | 0.94 | 0.37 - 2.39 | 0.900 | - | - | - |
| 3 | 3/3 | 4.36 | 1.26 - 15.01 | 0.020 | - | - | - |
| TNM stage | |||||||
| I | 6/26 | - | - | - | - | - | - |
| II | 13/32 | 2.07 | 0.78 - 5.44 | 0.142 | 6.05 | 1.33-27.54 | 0.02 |
| III | 19/52 | 1.86 | 0.74 - 4.67 | 0.184 | 5.6 | 1.29-24.29 | 0.021 |
| IV | 4/5 | 6.03 | 1.69 - 21.61 | 0.006 | 18.57 | 2.97-116.05 | 0.002 |
| Albumin (g/L) | |||||||
| >= 35 | 30/98 | - | - | - | - | - | - |
| < 35 | 13/25 | 2.01 | 1.05 - 3.85 | 0.036 | - | - | - |
| Pre-albumin (mg/L) | |||||||
| >= 280 | 6/17 | - | - | - | - | - | - |
| < 280 | 37/105 | 1.04 | 0.44 - 2.45 | 0.937 | - | - | - |
| CRP(mg/L) | |||||||
| <= 8.2 | 18/65 | - | - | - | - | - | - |
| > 8.2 | 19/38 | 2.41 | 1.26 - 4.61 | 0.008 | 2.24 | 1.15-4.38 | 0.018 |
| Ferritin (ng/mL) | |||||||
| <= 200 | 18/60 | - | - | - | - | - | - |
| > 200 | 8/23 | 1.05 | 0.46 - 2.41 | 0.912 | - | - | - |
| Surgery | |||||||
| No | 3/7 | - | - | - | - | - | - |
| Yes | 40/116 | 0.73 | 0.23 - 2.38 | 0.606 | - | - | - |
| Chemotherapy | |||||||
| No | 6/14 | - | - | - | - | - | - |
| Yes | 37/108 | 0.92 | 0.39 - 2.20 | 0.856 | - | - | - |
| Radiotherapy | |||||||
| No | 5/13 | - | - | - | - | - | - |
| Yes | 38/110 | 1.09 | 0.43 - 2.80 | 0.854 | - | - | - |