Table 2.
Drug dosing for the endTB-Q experimental arm
| Drug | Weight band (kg) | |
|---|---|---|
| 24–30 | > 30 | |
| Bedaquiline | 200 mg daily for 2 weeks followed by 100 mg 3 × /week | 400 mg daily × 2 weeks followed by 200 mg 3 × /week |
| Clofazimine | 100 mg daily | 100 mg daily |
| Delamanid | 50 mg twice daily | 100 mg twice daily |
| Linezolida | 300 mg daily up to week 16 (followed by 300 mg daily or 600 mg 3 × /week) | 600 mg daily up to week 16 (followed by 300 mg daily or 600 mg 3 × /week) |
aLinezolid dosing is routinely modified at week 16, or sooner if necessary, to reduce toxicity related to linezolid. The modification is either decreased (300 mg daily) or intermittent (600 mg 3 × /week) dosing as defined by a balanced secondary randomization