Table 6. Effect of Different Doses of F.A on pH, Urinary Volume, Na+ and K+ Excretion, Na+/K+ Ratio, Creatinine, and Uric Acid in Acute Diuretic Activitya.
| treatment groups | pH | urine volume mL/100 g 8 h | Na+(mmol/L) | K+(mmol/L) | Na+/K+ | creatinine (mg/dL) | uric acid (mg/dL) |
|---|---|---|---|---|---|---|---|
| C.G | 7.27 ± 0.10 | 2.33 ± 0.12 | 136.10 ± 0.55 | 25.0 ± 1.04 | 5.45 ± 0.21 | 1.37 ± 0.01 | 4.37 ± 0.09 |
| furosemide (15 mg/kg) | 7.74 ± 0.079* | 4.76 ± 0.35*** | 182.56 ± 0.76*** | 44.03 ± 0.49*** | 4.14 ± 0.03*** | 2.14 ± 0.02*** | 7.78 ± 0.19*** |
| F.A (100 mg/kg) | 7.63 ± 0.12* | 3.06 ± 0.20 | 142.16 ± 1.48** | 29.51 ± 0.82* | 4.82 ± 0.16* | 0.91 ± 0.04** | 6.86 ± 0.18*** |
| F.A (200 mg/kg) | 7.76 ± 0.10* | 3.50 ± 0.17 ** | 173.13 ± 1.04*** | 33.96 ± 0.98*** | 5.10 ± 0.17 | 1.63 ± 0.08 | 7.23 ± 0.03*** |
| F.A (400 mg/kg) | 7.90 ± 0.05** | 4.90 ± 0.11*** | 182.26 ± 0.72*** | 44.51 ± 0.75*** | 4.09 ± 0.08*** | 2.21 ± 0.11*** | 7.9 ± 0.17*** |
a
Results are stated as mean ± SEM, where *p < 0.05, **p < 0.01, and ***p < 0.001, as when compared to the control group. All data are subjected to one-way ANOVA followed by Dunnett’s post-test; C.G = Control group, Na+/K+ = Urinary excretion of sodium/urinary excretion of potassium.