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. 2023 Nov 15;8(47):44880–44892. doi: 10.1021/acsomega.3c05638

Table 8. Effect of Daily Administration of F.A (400 mg/kg) for 7 Days on Oxidative Stress Biomarkersa.

oxidative stress markers treatment groups heart liver kidney spleen
SOD (μg/mg of tissue protein) C.G 4.16 ± 0.064 0.966 ± 0.021 5.664 ± 0.055 9.882 ± 0.069
furosemide (15 mg/kg) 22.54 ± 0.303*** 0.984 ± 0.039 5.052 ± 0.099** 6.758 ± 0.108***
F.A (400 mg/kg) 24.64 ± 0.232*** 0.948 ± 0.024 6.758 ± 0.108*** 12.58 ± 0.091***
NO (μg/mg of tissue protein) C.G 26.26 ± 0.422 2.79 ± 0.037 9.38 ± 0.027*** 39.18 ± 0.108
furosemide (15 mg/kg) 36.45 ± 0.33*** 3.32 ± 0.044 19.75 ± 0.85*** 34.51 ± 1.039***
F.A (400 mg/kg) 36.33 ± 0.33*** 3.88 ± 0.031 18.64 ± 0.624*** 46.71 ± 0.626***
GSH (μg/mg of tissue protein) C.G 54.26 ± 0.58 3.64 ± 0.058 20.14 ± 0.59 69.38 ± 0.87
furosemide (15 mg/kg) 41.95 ± 0.57*** 4.54 ± 0.24 26.14 ± 0.59*** 45.37 ± 0.31***
F.A (400 mg/kg) 46.14 ± 0.59*** 6.86 ± 0.10*** 28.76 ± 0.14*** 87.55 ± 0.23***
MDA (μmol/mg of tissue protein) C.G 0.95 ± 0.012 0.14 ± 0.017 1.20 ± 0.14 2.07 ± 0.06
furosemide (15 mg/kg) 0.94 ± 0.023 0.14 ± 0.009 0.907 ± 0.022** 1.55 ± 0.020***
F.A (400 mg/kg) 0.85 ± 0.023 0.13 ± 0.023 0.633 ± 0.012*** 1.86 ± 0.009*
a

All of the results are shown as mean ± SEM, whereas ** P < 0.01 and *** P < 0.001 when compared to the control group. All data are subjected to two-way ANOVA followed by Bonferroni’s post-test.