Table 8. Effect of Daily Administration of F.A (400 mg/kg) for 7 Days on Oxidative Stress Biomarkersa.
oxidative stress markers | treatment groups | heart | liver | kidney | spleen |
---|---|---|---|---|---|
SOD (μg/mg of tissue protein) | C.G | 4.16 ± 0.064 | 0.966 ± 0.021 | 5.664 ± 0.055 | 9.882 ± 0.069 |
furosemide (15 mg/kg) | 22.54 ± 0.303*** | 0.984 ± 0.039 | 5.052 ± 0.099** | 6.758 ± 0.108*** | |
F.A (400 mg/kg) | 24.64 ± 0.232*** | 0.948 ± 0.024 | 6.758 ± 0.108*** | 12.58 ± 0.091*** | |
NO (μg/mg of tissue protein) | C.G | 26.26 ± 0.422 | 2.79 ± 0.037 | 9.38 ± 0.027*** | 39.18 ± 0.108 |
furosemide (15 mg/kg) | 36.45 ± 0.33*** | 3.32 ± 0.044 | 19.75 ± 0.85*** | 34.51 ± 1.039*** | |
F.A (400 mg/kg) | 36.33 ± 0.33*** | 3.88 ± 0.031 | 18.64 ± 0.624*** | 46.71 ± 0.626*** | |
GSH (μg/mg of tissue protein) | C.G | 54.26 ± 0.58 | 3.64 ± 0.058 | 20.14 ± 0.59 | 69.38 ± 0.87 |
furosemide (15 mg/kg) | 41.95 ± 0.57*** | 4.54 ± 0.24 | 26.14 ± 0.59*** | 45.37 ± 0.31*** | |
F.A (400 mg/kg) | 46.14 ± 0.59*** | 6.86 ± 0.10*** | 28.76 ± 0.14*** | 87.55 ± 0.23*** | |
MDA (μmol/mg of tissue protein) | C.G | 0.95 ± 0.012 | 0.14 ± 0.017 | 1.20 ± 0.14 | 2.07 ± 0.06 |
furosemide (15 mg/kg) | 0.94 ± 0.023 | 0.14 ± 0.009 | 0.907 ± 0.022** | 1.55 ± 0.020*** | |
F.A (400 mg/kg) | 0.85 ± 0.023 | 0.13 ± 0.023 | 0.633 ± 0.012*** | 1.86 ± 0.009* |
All of the results are shown as mean ± SEM, whereas ** P < 0.01 and *** P < 0.001 when compared to the control group. All data are subjected to two-way ANOVA followed by Bonferroni’s post-test.