Fig 1.
RSV preF-specific humoral immune responses induced by Ad26.RSV.preF and the Ad26.RSV.preF/RSV preF protein combination vaccine. (a) IgG1, (b) IgA1, and (c) IgM GMFIs were measured in serum samples collected on days 1 (pre-vaccination), 15, 29, and 183 from participants receiving Ad26.RSV.preF alone (n = 12), the Ad26.RSV.preF/RSV preF protein combination vaccine (n = 42), or placebo (n = 6). Statistical comparisons were performed by analysis of variance (Kruskal-Wallis) with a Benjamini-Hochberg correction for multiple comparisons. Error bars denote 95% CIs. *P ≤ 0.05; **P ≤ 0.01; ***P < 0.001. Ad26, adenovector type 26; CI, confidence interval; GMFI, geometric mean fold increase; Ig, immunoglobulin; preF, pre-fusion conformation-stabilized RSV F protein; RSV, respiratory syncytial virus.