Fig 4.

HIVε-seq categories by viral levels measured with QVOA and IPDA. (A) Frequency of replication-competent persistent provirus in HIV-1 infected adults on ART with fully suppressed viremia on days 15 and 19 (B) measured by the QVOA assay or (C) frequency of total DNA and intact DNA (D) as measured by IPDA compared to HIVε-seq category. No amplification—no reads map to HXB2 reference. Amplification—reads that map to HXB2 and contain 5′ and 3′ PCR primer binding sites. Full-length—reads mapping to greater than 8,500 bp of HXB2 reference. No stops—full-length reads with no stop codons detected in protein-coding regions. Intact—no stop reads without known regulatory region defects. Colors denote individual participants. Asterisks indicate P-value less than 0.05.