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. 2023 Nov 10;19(11):e1011026. doi: 10.1371/journal.pgen.1011026

Fig 7. NES-mediated nuclear export of Pch2 is essential for meiotic recombination checkpoint function.

Fig 7

The nucleocytoplasmic transport of Pch2 via the exportin pathway maintains Pch2 homeostasis and supports proper checkpoint activity in zip1Δ. In the NES-deficient pch2-nes4A mutant, the accumulation of Pch2 in the nucleus leads to checkpoint inactivation. The fusion to Pch2-nes4A of a characterized ectopic NES from the PKI protein, or a putative NES from the human TRIP13 ortholog, restores the balanced subcellular distribution of Pch2 and restores checkpoint function. For simplicity, the NES is drawn only in one subunit of the Pch2 hexamer. BioRender.com was used to create this figure.