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. 2023 Oct 20;12:e85175. doi: 10.7554/eLife.85175

Table 1. Summary of differences between two obesity-associated micro-structural MRI phenotypes in terms of their associations with other brain phenotypes (gene ontology, receptor expression, and cell types) and their genetic correlations with obesity.

Scaling with obesity (WHR) Gene ontology Neurotransmitter receptors or transporters Cell types Genetic correlation with WHR
ISOVF (free water) Inline graphic prefrontal-temporo-striatal system Inline graphic pattern recognition receptors (PRR)
Inline graphic receptors for fatty acid derivatives
Inline graphic IL-6 responses		 Inline graphic H3, Mu, D1 and 5HTT Inline graphic astrocytes, microglia and oligodendrocyte precursor cells (not any class of neurons) Inline graphic not significant
ICVF (neurite density) Inline graphic medial temporal-occipito-striatal system Inline graphic taste receptor activity
Inline graphic fatty acid receptors, glutamate receptor activity and GPCR signalling		 Inline graphic H3, Mu, CB1 and A4B2 Inline graphic not significant Inline graphic significant (positive)