. 2023 Nov 30;9(6):e200109. doi: 10.1212/NXG.0000000000200109

Table 1.

Pooled Proportion of ALS Cases That Are Familial (fALS), According to Geographic Region and Study Type

Region	Studies	fALS cases	Total ALS cases	Estimate (lower limit, upper limit)
Asia	24	332	7,748	0.04 (0.03, 0.06)^a
Case series	23	331	7,664	0.05 (0.03, 0.06)^a
Population-based	1	1	84	0.01 (NA, NA)
Australasia	4	30	432	0.08 (0.04, 0.16)^a
Case series	3	20	188	0.12 (0.08, 0.17)^a
Population-based	1	10	244	0.04 (NA, NA)
Europe	77	2,783	30,553	0.09 (0.00, 0.71)
Case series	40	1,848	16,730	0.11 (0.00, 0.71)
Population-based	37	935	13,823	0.06 (0.05, 0.07)^a
Latin America	17	275	2,518	0.06 (0.04, 0.09)^a
Case series	12	237	1,708	0.07 (0.05, 0.12)^a
Population-based	5	38	810	0.05 (0.03, 0.07)^a
Middle East and North Africa	10	159	1,832	0.09 (0.01, 0.40)
Case series	9	154	1,750	0.09 (0.01, 0.40)
Population-based	1	5	82	0.06 (NA, NA)
North America	28	975	16,989	0.06 (0.05, 0.08)^a
Case series	16	479	6,705	0.08 (0.06, 0.10)^a
Population-based	12	496	10,284	0.05 (0.04, 0.06)^a
Sub-Saharan Africa	5	23	514	0.05 (0.03, 0.07)^a
Case series	4	15	329	0.05 (0.03, 0.09)^a
Population-based	1	8	185	0.04 (NA, NA)
Overall	165	4,577	60,586	0.08 (0.00, 0.71)
Case series	107	3,084	35,074	0.09 (0.00, 0.71)
Population-based	58	1,493	25,512	0.05 (0.04, 0.06)^a

Abbreviation: ALS = amyotrophic lateral sclerosis; NA = not applicable.

Random-effects meta-analytic estimates and corresponding 95% confidence intervals are presented (>2 and I² < 90%). Otherwise, weighted averages and ranges are presented.