Table 4:
Biomarker: association and risk prediction for cardiovascular events.
| Biomarker | Unadjusted OR (95%CI) |
P-value | Adjusted OR (95%CI)a |
P-value | AUROC (95%CI) |
|---|---|---|---|---|---|
| Pre-angiography | |||||
| Urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1000 | 0.91 (0.65–1.27) |
.58 | 0.88 (0.63–1.24) |
.47 | 0.49 (0.44–0.55) |
| Log urine creatinine-indexed urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1000 mg/dL | 1.16 (0.94–1.43) |
.17 | 1.10 (0.88–1.36) |
.39 | 0.55 (0.49–0.61) |
| Log plasma BNP, pg/mL | 1.85 (1.56–2.21) |
<.001 | 1.71 (1.42–2.06) |
<.001 | 0.69 (0.64–0.75) |
| Serum troponin-I, ng/mL | 1.07 (1.01–1.12) |
.01 | 1.06 (1.00–1.12) |
.03 | 0.63 (0.58–0.69) |
| Plasma hs-CRP, mg/L | 1.12 (1.07–1.18) |
<.001 | 1.11 (1.05–1.17) |
<.001 | 0.65 (0.58–0.72) |
| Post-angiography | |||||
| Urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1000 | 1.11 (0.72–1.73) |
.62 | 1.00 (0.64–1.57) |
.99 | 0.51 (0.46–0.57) |
| Log urine creatinine-indexed urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1000 mg/dL | 1.15 (0.88–1.51) |
.29 | 1.05 (0.79–1.40) |
.72 | 0.52 (0.46–0.58) |
| Log plasma BNP, pg/mL | 1.83 (1.53–2.20) |
<.001 | 1.69 (1.34–2.06) |
<.001 | 0.68 (0.63–0.74) |
| Serum troponin-I, ng/mL | 1.07 (1.00–1.15) |
.04 | 1.07 (1.00–1.14) |
.04 | 0.64 (0.58–0.70) |
| Plasma hs-CRP, mg/L | 1.12 (1.06–1.18) |
<.001 | 1.11 (1.05–1.18) |
<.001 | 0.66 (0.59–0.74) |
a
Adjusted for baseline eGFR and urine albumin-creatinine ratio.