Table 5:
Summary of patients who had interrupted upacicalcet due to serum corrected calcium level of <7.5 mg/dL.
| Serum corrected calcium (mg/dL) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Patient No. | Interruption week | Upacicalcet dose before interruption | Baseline | Interruption week | + 1-weeka | + 2-weeka | + 3-weeka | + 4-weeka | Resumed week (upacicalcet dose) |
| 1 | Week 1 | 50 μg | 8.9 | 7.3 | 8.4 | 8.5 | 8.0 | 7.7 | + 2-weeka, (25 μg) |
| 2 | Week 1 | 50 μg | 8.8 | 7.4 | 8.5 | 9.2 | 8.5 | 8.0 | + 2-weeka, (25 μg) |
| 3 | Week 1 | 50 μg | 8.9 | 7.4 | 8.4 | 8.6 | 8.0 | 7.8 | + 2-weeka, (25 μg) |
| 4 | Week 1 | 50 μg | 8.7 | 7.3 | 8.5 | 8.7 | 8.0 | 7.7 | + 2-weeka, (25 μg) |
| 5 | Week 1 | 50 μg | 8.4 | 7.3 | 8.7 | 8.6 | 7.8 | 7.9 | + 2-weeka, (25 μg) |
| 6 | Week 1 | 50 μg | 8.9 | 7.4 | 8.6 | 8.7 | 7.6 | 7.7 | + 2-weeka, (25 μg) |
| 7 | Week 2 | 50 μg | 8.4 | 7.2 | 7.9 | 8.3 | 8.2 | Discontinuation c | |
| 8 | Week 7 | 25 μg | 8.7 | 7.4 | 8.0 | 8.0 | 8.8 | 9.0 | + 3-weeka, (25 μg) |
| 9 | Week 5 | 50 μg | 8.4 | 7.4 | 8.1 | 8.6 | 8.1 | 8.0 | + 2-weeka, (25 μg) |
| Week 15 | 50 μg | 8.4 | 7.4 | 8.5 | 7.9 | 7.9 | –b | + 1-weeka, (25 μg) | |
a
Time points after interruption.
b
Not measured (for transition to Treatment Period 2).
c
Reason of discontinuation: investigator's decision.