Table 1:
Demographic data and kidney biopsy findings.
| N (%) with data | Mean | SD | Median (range) | |
|---|---|---|---|---|
| Male | 65 (63) | |||
| Age at diagnosis (1st biopsy) (years) | 103 | 44.6 | 16.3 | 44 (11 to 92) |
| Age at baseline (years) | 103 | 53.9 | 15.4 | 54 (20 to 92) |
| eGFR at baseline (mL/min/1.73 m2) | 94 | 56.4 | 27.4 | 52.5 (8.9 to 117) |
| eGFR at follow-up (mL/min/1.73 m2) | 77 | 54.5 | 28.6 | 51.6 (8 to 125) |
| Number of antihypertensive drugs at baseline (N) | 103 | 2.0 | 1.38 | 2 (0 to 6) |
| Biopsy: glomerular sclerosis (% of glomeruli) | 85 | 19 | 16 | 14 (0 to 70) |
| Biopsy: interstitial fibrosis (% of kidney surface) | 93 | 23 | 18 | 25 (0 to 70) |
| Biopsy: crescents (% of biopsies with crescents)a | 25/91 (27.5%) | |||
| Baseline (at IgAN237-1) | ||||
| Time between biopsy and urine sample 1 (months) | 103 | 119.1 | 130.6 | 65 (0 to 606) |
| IgAN237-1 (value) | 103 | –0.0116 | 0.802 | 0.024 (–2.163 to 2.038) |
| Hematuria [N (%)] | 85 [38 (45%)] | |||
| UACR (g/mol) | 94 | 48.2 | 83.6 | 19.0 (0.5 to 655) |
| UACRTotal-slope (g/mol/year) | 96 | –28.1 | 107 | –2.79 (–745 to 18.8) |
| UACRChron-slope (g/mol/year) | 95 | –5.36 | 27.0 | –0.40 (–226 to 30.7) |
| UACRProsp-slope (g/mol/year) | 87 | –5.98 | 55.4 | 0.00 (–226 to 324) |
| UACR180days-slope (g/mol/year) | 87 | –11.1 | 122 | 0.00 (–1085 to 163) |
| Follow-up (at IgAN237-2) | ||||
| Time between urine sample 1 and 2 (days) | 89 | 271 | 78 | 258 (71 to 531) |
| IgAN237-2 (value) | 89 | –0.069 | 0.741 | 0.054 (–2.119 to 1.721) |
| Hematuria [N (%)] | 46 [18 (39%)] | |||
| UACR (g/mol) | 64 | 38.0 | 47.9 | 21.6 (0.30 to 250) |
| UACRTotal-slope (g/mol/year) | 85 | –25.2 | 100 | –2.74 (–745 to 18.8) |
| UACRChron-slope (g/mol/year) | 84 | –3.67 | 14.8 | –0.38 (–67.9 to 30.7) |
| UACRProsp-slope (g/mol/year) | 62 | 15.7 | 283 | 0.00 (–1160 to 1840) |
| UACR180days-slope (g/mol/year) | 62 | –9.98 | 55.3 | –0.16 (–238 to 147) |
N = number; SD = standard deviation.
Baseline is the timepoint when the first urine sample for assessment of IgAN237 was collected.
In one biopsy, one endocapillary finding was mentioned.
aIn those with crescent findings, few affected glomeruli were noted.