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. 2023 Nov 30;223(1):e202307150. doi: 10.1083/jcb.202307150

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© 2023 Lyu et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Figure 1. — Regulation of MCC cell fate determination. The Notch signaling pathway inhibits the differentiation of MCC progenitor cells that express P63 and SOX2. Upon the activation of MCC differentiation, miR-34/449 can inhibit the Notch signaling pathway, which leads to the expression of key regulators, including TRRAP, GEMC1, and MCIDAS. GEMC1 induces cell cycle exit through the P53-P21 pathway and acts upstream of MCIDAS and C-MYB to control the expression of centriole amplification-related regulators such as DEUP1, CCNO, and CDC20B. On the other hand, GEMC1, C-MYB, and P73 can regulate the expression of motile cilia-related master regulators such as FOXJ1, RFX2, and RFX3.