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. 2023 Nov 13;26(12):2104–2121. doi: 10.1038/s41593-023-01480-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Representative images of 10-month-old PS19-E4, PS19-E3, PS19-E4-S/S and PS19-E4-R/S mouse brain sections stained with Sudan black to enhance hippocampal visualization (scale bar, 1 mm). b,c, Quantification of hippocampal volume (WT, n = 11; PS19-E4, n = 31; PS19-E3, n = 23; PS19-E4-S/S, n = 20; PS19-E4-R/S, n = 23; n = mice) (b) and posterior lateral ventricle volume (PS19-E4, n = 30; PS19-E3, n = 23; PS19-E4-S/S, n = 20; PS19-E4-R/S, n = 23; n = mice) (c). d,e, Correlation of the APOE4-R136S gene copy number with the average of hippocampal volume (PS19-E4, n = 31; PS19-E4-S/S, n = 20; PS19-E4-R/S, n = 23; n = mice) (d) or the average of posterior lateral ventricle volume (PS19-E4, n = 30; PS19-E4-S/S, n = 20; PS19-E4-R/S, n = 23; n = mice) (e) in PS19-E4 mice with 0, 1 or 2 copies of the APOE4-R136S gene mutation. f–i, Correlations between percent AT8 coverage area and hippocampal volume in 10-month-old PS19-E4 (n = 29) (f), PS19-E3 (n = 21) (g), PS19-E4-S/S (n = 19) (h) and PS19-E4-R/S (n = 22) (i) mice. j, Representative images of the DG stained for NeuN in 10-month-old PS19-E4, PS19-E3, PS19-E4-S/S and PS19-E4-R/S mice (scale bar, 100 μm). k, Quantification of DG GC layer thickness in 10-month-old PS19-E4 (n = 30), PS19-E3 (n = 23), PS19-E4-S/S (n = 20) and PS19-E4-R/S (n = 23) mice. Throughout, data are expressed as mean ± s.e.m. except for correlation plots. Differences between groups were determined by ordinary one-way ANOVA followed by Tukey’s multiple comparison test (b,k) or Welch’s ANOVA followed by Dunnett’s T3 multiple comparison test (c). Comparisons of P ≤ 0.05 are labeled on the graph. Pearson’s correlation analysis (two-sided). LV, lateral ventricle.

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