Table 1.
Patient Characteristics of the First-Line Cohort
| Characteristics | N = 26 | |
|---|---|---|
| Age, y | Median | 72.0 |
| Range | 55–82 | |
| Gender, n (%) | Male | 5 (19.2) |
| Female | 21 (80.8) | |
| Stage at diagnosis, n (%) | IV | 19 (73.1) |
| Postoperative | 7 (26.9) | |
| ECOG performance status, n (%) | 0 | 9 (34.6) |
| 1 | 15 (57.7) | |
| 2 | 2 (7.7) | |
| Histological type, n (%) | Adenocarcinoma | 25 (96.2) |
| Others | 1 (3.8) | |
| Smoking history, n (%) | Current or former | 9 (34.6) |
| Never | 17 (65.5) | |
| EGFR mutation type, n (%) | Exon 19 deletion | 15 (57.7) |
| L858R | 11 (42.3) | |
| CNS lesion, n (%) | Single | 6 (23.1) |
| Multiple | 20 (76.9) | |
| Symptomatic CNS metastasis, n (%) | Present | 4 (15.4) |
| Absent | 21 (80.8) | |
| Unknown | 1 (3.8) | |
| Baseline CNS target lesion size | Median | 8.7 mm |
| Range | 5.0–49.6 mm |
CNS, central nervous system; ECOG, Eastern Cooperative Oncology Group.