Table 2.
Abundance differences and prognosis of different bacterial communities in gastrointestinal tumours
| Type | Intestinal microbiota | Reference |
|---|---|---|
| Colorectal cancer | In the gut of colorectal cancer patients, the abundance of Oral Peptostreptococcus, Proteus, Fusobacterium nucleatum, Escherichia coli fragilis and Enterococcus faecalis was high, while the abundance of Rothia, Clostridium, Faecal Bacillus and Bifidobacterium was generally reduced | [101, 102] |
| Colorectal cancer | Significant enrichment of Fusobacterium nucleatum could serve as a biomarker for colorectal cancer (AUC: 0.8) and were associated with a poor prognosis | [103] |
| Colorectal cancer | 11 metabolite markers (2-hydroxybutyric acid, gamma-aminobutyric acid, L-alanine, L-aspartic acid, norvaline, ornithine, oxoadipic acid, oxoglutaric acid, palmitoleic acid, phenylacetic acid and pimelic acid) and 6 bacterial species (Fusobacterium nucleatu, Peptostreptococcus anaerobius, Peptostreptococcus micros, Ruminiclostridium inulinivorans, Eikenella corrodens and Xanthomonas. perforin) achieved a higher AUC of 0.9417 | [104] |
| Colorectal cancer | Bacillus fragilis and faecal bacteria were positively correlated with prognosis. Fusobacterium nucleatum and Bacteroides fragilis were negatively correlated with prognosis.a | [105] |
| Gastric cancer | The aerobic bacteria (streptococci and enterococci) and facultative anaerobes (Escherichia, Enterobacter and Streptococcus) in gastric cancer patients increased significantly after gastrectomy because of the increase of intestinal oxygen and the translocation of oral flora | [32] |
| Gastric cancer | After chemotherapy, the PFS of gastric cancer patients with increased R. faeces abundance was longer | [106] |
| Hepatocellular Carcinoma | Butyrate-producing bacteria decreased significantly, such as Ruminococcus, Oscillibacter, Faecalibacterium, Clostridium IV and Coprococcus, while there was an increase in Klebsiella and Haemophilus that produce Lipopolysaccharides | [107] |
| Hepatocellular Carcinoma | The abundance of Blautia was positively correlated with progression-free survival and overall survival in liver cancer patients undergoing chemotherapy | [108] |
| Hepatocellular Carcinoma | Significant enrichment of Bacteroides, Lachnospiracea incertae sedis, and Clostridium XIVa in liver cancer patients was associated with poor clinical prognosis | [109] |
| Oesophageal cancer | The abundance of Streptococcus, Prevobacter, Clostridium, Velococcus and Lactobacillus increased in patients with oesophageal cancer | [110] |
| Oesophageal cancer | Streptococcus and Prevotella are biomarkers of poor prognosis in oesophageal cancer | [111] |
| Pancreatic Cancer | Studies have shown that the abundance of Veillonella atypica, Fusobacterium nucleatum/hwasookii and Alloscardovia omnicolens in pancreatic cancer tissues and stool samples is significantly increased | [112] |
| Pancreatic Cancer | The poor prognosis of pancreatic cancer was associated with the Fusobacterium | [113] |
Abbreviations: AUC Area under the curve