Table 3.

Mortality effect size estimates derived from simulated CRT array*

	OR	Oral care (tier 2)	OR	TAP (tier 3)
		95% CI		95% CI
CRT estimates (unadjusted)†
Direct effect	1.11	0.78 to 1.43	1.25	0.94 to 1.57
Indirect effect	1.28	0.92 to 1.64	1.64	1.23 to 2.05
CRT estimates (adjusted)‡
Direct effect	1.10	0.77 to 1.43	1.04	0.78 to 1.30
Indirect effect	1.26	0.89 to 1.62	1.39	1.03 to 1.74

*These effect size estimates are derived using the RCCTs of the tier 1 interventions as a benchmark group.

†CRT estimates (unadjusted estimates) come from online supplemental table S9 model 1. This model includes 460 groups from the 209 studies whether reporting ICU (Intensive Care Unit) or late mortality.

‡CRT estimates (adjusted estimates) come from online supplemental table S9 model 2 and are adjusted for group mean age, year of study publication, proportion receiving MV>90% and majority quality score. This model includes 428 groups from the 209 studies whether reporting ICU or late mortality.

CRT, cluster randomised trial; ICU, Intensive Care Unit; MV, mechanical ventilation; RCCT, randomised concurrent controlled trial.