Table 1.
Basic characteristics
| Variable | All admissions (n=192) | SRD related (n=56) | Co-existent SRD (n=136) | P value |
| Age (years), median (IQR) | 61 (45–71) | 45 (30–64) | 65 (51–73) | <0.001 |
| Female sex (%) | 120 (62.5) | 38 (67.9) | 82 (60.3) | 0.325 |
| SOFA, median (IQR) | 9 (6–11) | 9 (7–12) | 9 (6–11) | 0.354 |
| SAPSII, median (IQR) | 45 (35–55) | 41 (27–49) | 46 (38–57) | 0.006 |
| APACHEII, median (IQR) | 21 (16–26.3) | 18 (14–25) | 23 (17–27) | 0.005 |
| CCI, median (IQR) | 4 (3–6) | 3 (1–5) | 5 (4–6) | <0.001 |
| SRD diagnosed in ICU, No. (%) | 21 (10.9) | 16 (28.6) | 5 (3.7) | <0.001 |
| SRD type | ||||
| CTD, No. (%) | 59 (30.7) | 24 (42.9) | 35 (25.7) | 0.025 |
| Vasculitis, No. (%) | 55 (28.6) | 24 (42.9) | 31 (22.8) | 0.008 |
| RA, No. (%) | 35 (18.2) | 1 (1.8) | 34 (25.0) | <0.001 |
| SpA, No. (%) | 12 (6.3) | 0 (0) | 12 (8.8) | 0.019 |
| Other, No. (%) | 31 (16.1) | 7 (12.5) | 24 (17.6) | 0.518 |
| SRD-related organ involvement | ||||
| Respiratory system, No. (%) | 88 (45.8) | 42 (75.0) | 46 (33.8) | <0.001 |
| Nervous system, No. (%) | 17 (8.9) | 12 (21.4) | 5 (3.7) | <0.001 |
| Heart and circulation, No. (%) | 14 (7.3) | 8 (14.3) | 6 (4.4) | 0.029 |
| GI and liver, No. (%) | 34 (17.7) | 13 (23.2) | 21 (15.4) | 0.302 |
| Blood and coagulation, No. (%) | 29 (15.1) | 13 (23.2) | 16 (11.8) | 0.074 |
| Kidney | 67 (34.9) | 35 (62.5) | 32 (23.5) | <0.001 |
| ≥2 organ involvements, No. (%) | 82 (42.7) | 44 (78.6) | 38 (27.9) | <0.001 |
| Reason for ICU admission | ||||
| Shock, No. (%) | 46 (24.0) | 9 (16.1) | 37 (27.2) | 0.136 |
| Cardiogenic event, No. (%) | 22 (11.5) | 1 (1.8) | 21 (15.4) | 0.005 |
| Respiratory failure, No. (%) | 91 (47.4)* | 32 (57.1) | 59 (43.4)* | 0.111 |
| Neurologic failure, No. (%) | 20 (10.4) | 5 (8.9) | 15 (11.0) | 0.798 |
| Urgent surgery, No. (%) | 7 (3.6) | 5 (8.9) | 2 (1.5) | 0.023 |
| Other, No. (%) | 5 (2.6) | 4 (7.1) | 2 (1.5) | 0.061 |
| Origin of patients | ||||
| Rheumatology ward | 39 (20.3) | 17 (30.4) | 22 (16.2) | 0.031 |
| Normal ward | 87 (45.3) | 15 (26.8) | 72 (52.9) | 0.001 |
| ICU/emergency room | 66 (34.4) | 24 (42.9) | 42 (30.9) | 0.133 |
| IS naive at hospital admission, No. (%) | 62 (32.3) | 31 (55.4) | 31 (22.8) | <0.001 |
| GC naive at hospital admission, No. (%) | 45 (23.4) | 24 (42.9) | 21 (15.4) | <0.001 |
| IS naive at ICU admission, No. (%) | 46 (24.0) | 25 (44.6) | 21 (15.4) | <0.001 |
| GC naive at ICU admission, No. (%) | 25 (13.0) | 10 (17.9) | 15 (11.0) | 0.073 |
*Two Patients had respiratory failure due to COVID-19.
APACHEII, Acute Physiology and Chronic Health Evaluation II Score; CCI, Charlson Comorbidity Index; CTD, connective tissue disease; GC, glucocorticoid; GI, gastrointestinal tract; ICU, intensive care unit; IQR, interquartile range; IS, immunosuppressive/immunomodulatory therapy; No., number of patients; No., number of patients; RA, rheumatoid arthritis; SAPSII, Simplified Acute Physiology Score II; SOFA, Sequential Organ Failure Assessment Score; SpA, seronegative spondyloarthropathies; SRD, systemic rheumatic disease.