TABLE 3.
Characteristics of FKBPs
| FKBP | Organisms | Size (aa)b of:
|
PPIase activitya | FK506 sensitivitya | Molecular mass (kDa) | Reference | Swiss-Prot accession no. | |
|---|---|---|---|---|---|---|---|---|
| Bulge | Flap | |||||||
| Eucarya | ||||||||
| hFKBP12 | Human | 7 | 20 | + | + | 12 | 12 | P20071 |
| scFKBP | S. cerevisiae | 7 | 20 | + | + | 12 | 24 | P32472 |
| ncFKBP | N. crassa | 7 | 20 | + | + | 13 | 38 | P20080 |
| Bacteria | ||||||||
| lpMIP | L. pneumophila | 7 | 20 | + | + | 26 | 9 | P20380 |
| ecFKBY | E. coli | 7 | 20 | + | + | 22 | 28 | P39311 |
| ecFKBX | E. coli | 7 | 68 | + | − | 16 | 15 | P22563 |
| pfFKBP | P. fluorescens | 6 | 67 | ND | ND | 16 | 17 | P21863 |
| ecSlyD | E. coli | 6 | 67 | + | − | 21 | 15 | P03856 |
| ecTIG | E. coli | 5 | 15 | + | − | 48 | 34 | P22257 |
| Archaea | ||||||||
| MTFK | M. thermolithotrophicus | 20 | 64 | + | + | 16 | This study | |
| MJFK | M. jannaschii | 20 | 64 | ND | ND | 16 | 4 | Q58235 |
a
ND, not determined; +, positive in activity or sensitivity; −, negative in sensitivity.
b
aa, amino acids.