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. 2023 Oct 27;17(12):2370–2380. doi: 10.1038/s41396-023-01537-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The stability of the human gut microbiome was calculated as 1 minus the UniFrac distance between the two time points in the longitudinal studies and correlated with the abundance-weighted average of auxotrophies at the first time point to study a potential influence of auxotrophies on the long-term stability of the human gut microbiome. B The average Hamming distance was calculated for the first time point and then correlated with the 1-UniFrac value to investigate the influence of potential cross-feeding on long-term stability. C The contribution of individual amino acid auxotrophies on the stability was calculated with the Spearman correlation between the 1-UniFrac values and individual amino acid auxotrophy frequencies.