. 2023 Nov 30;13:19870. doi: 10.1038/s41598-023-46741-5

Table 5.

Mixed-effects regression models of stimulus level effect as a function of tinnitus status and EHFs on MEMR variables.

Predictors	At highest magnitude			At highest gain			At lowest threshold
Predictors	Est	CI	p	Est	CI	p	Est	CI	p
MEMR thresholds
(Intercept)	80.214	75.653 to 84.775	< 0.001	70.625	65.615 to 75.636	< 0.001	60.767	53.320 to 65.215	< 0.001
Standard	− 0.615	− 1.348 to 0.117	0.099	0.633	− 0.152 to 1.417	0.113	0.587	− 0.128 to 1.302	0.106
EHFs	− 0.012	− 0.227 to 0.203	0.914	0.015	− 0.224 to 0.255	0.899	0.105	− 0.104 to 0.315	0.322
Chronic	6.501	1.178 to 11.824	0.017	7.567	1.538 to 13.597	0.014	4.494	− 0.692 to 9.679	0.089
Random effects
σ²	89.17			51.78			88.20
τ_∞	8.17_ID			56.16_ID			5.31_ID
ICC	0.08			0.52			0.06
N	71_ID			71_ID			71_ID
Observations	104			104			104
Marginal R²	0.074			0.122			0.107
Conditional R²	0.151			0.579			0.158

Predictors	500–2000 Hz window			500–5000 Hz window
Predictors	Est.	CI	p	Est.	CI	p
MEMR thresholds
(Intercept)	77.439	72.624 to 82.253	<0.001	73.269	69.234 to 77.305	<0.001
Standard	0.033	− 0.726 to 0.792	0.932	0.152	− 0.487 to 0.791	0.638
EHFs	− 0.065	− 0.294 to 0.165	0.576	0.074	− 0.118 to 0.266	0.446
Chronic	8.651	2.921 to 14.382	0.003	6.642	1.871 to 11.412	0.007
Random effects
σ²	57.50			43.53
τ_∞	42.49_ID			24.44_ID
ICC	0.42			0.34
N	71_ID			71_ID
Observations	104			104
Marginal R²	0.095			0.117
Conditional R²	0.480			0.421

Predictors	At highest magnitude			At highest gain			At lowest threshold
Predictors	Est.	CI	p	Est.	CI	p	Est.	CI	p
MEMR strength
(Intercept)	24.685	12.644 to 36.727	< 0.001	61.235	43.454 to 79.017	< 0.001	34.880	21.001 to 48.759	< 0.001
Standard	0.797	− 1.096 to 2.689	0.406	1.064	− 1.736 to 3.863	0.453	0.508	− 1.694 to 2.711	0.648
EHFs	− 0.071	− 0.646 to 0.503	0.806	− 0.316	− 1.164 to 0.532	0.461	− 0.052	− 0.712 to 0.608	0.875
Chronic	− 15.181	− 29.583 to − 0.780	0.039	− 17.001	− 38.215 to 4.213	0.115	− 17.021	− 33.398 to − 0.645	0.042
Random effects
σ²	329.96			751.79			576.10
τ_∞	293.68_ID			609.79_ID			267.49_ID
ICC	0.47			0.45			0.32
N	71_ID			71_ID			71_ID
Observations	104			104			104
Marginal R²	0.055			0.042			0.049
Conditional R²	0.500			0.471			0.350

Predictors	500–2000 Hz window			500–5000 Hz window
Predictors	Est.	CI	p	Est.	CI	p
MEMR strength
(Intercept)	12.983	8.767 to 17.199	< 0.001	119.275	85.23 to 153.32	< 0.001
Standard	0.278	− 0.387 to 0.944	0.409	3.175	− 2.120 to 8.470	0.237
EHFs	− 0.121	− 0.322 to 0.080	0.235	− 1.120	− 2.746 to 0.507	0.175
Chronic	− 3.825	− 8.832 to 1.182	0.133	− 37.812	− 79.234 to 3.609	0.073
Random effects
σ²	46.07			2054.45
τ_∞	30.80_ID			2956.94_ID
ICC	0.40			0.59
N	71_ID			71_ID
Observations	104			104
Marginal R²	0.051			0.072
Conditional R²	0.431			0.619

Adj. adjusted, Chronic chronic tinnitus group, CI confidence interval, EHFs thresholds at extended high frequencies, Est. estimates, Standard thresholds at standard audiometric frequencies.

Significant values are in bold.