Table 3.

Top-ranked associations in the exome-wide analysis

Gene	ID	Chr : position	Function	EA	RA	Minor Allele Frequency			OR	P-value *
						AD	Control	EUR
APOE	rs429358	19:44908684	exonic	C	T	0.28	0.12	0.16	2.79	4.52x10−52
TREM2	rs75932628	6:41161514	exonic	T	C	0.036	0.011	0.0023	3.16	2.64x10−10
SMAP2	rs1003710	1:40374681	5’ UTR	A	G	0.40	0.46	0.44	0.77	1.91x10−7
ZNF890P	rs200698976	7:5132414	intronic	TG	T	0.28	0.34	0.31	0.76	3.49x10−7
TRAPPC8	rs149840013	18:31839471	intronic	A	G	0.0042	0.028	0.0022	0.16	1.53x10−6
DMWD	rs138963867	19:45786302	exonic	A	G	0.021	0.0077	0.0013	2.98	1.78x10−6
OR7C2	rs113508813	19:14942161	exonic	A	G	0.033	0.054	0.000071	0.55	1.81x10−6
SLC43A3	rs117212150	11:57414602	intronic	T	C	0.099	0.068	0.015	1.52	2.19x10−6
DOCK9	rs2296984	13:98805177	exonic	G	T	0.21	0.17	0.20	1.34	3.26x10−6

^*significance threshold P=2.74x10⁻⁷

Chr: chromosome; EA: effect allele; RA: reference allele; EUR: European reference population; OR: odds ratio