Table 4.
Differential expression in brain of genes at top-ranked loci between AD cases and controls.
| Gene | Chr: pos | Z-score | P-value * |
|---|---|---|---|
| SMAP2 | 1:40344850 | −4.77 | 1.80x10−6 |
| RAB3B | 1:51907956 | −4.66 | 3.10x10−6 |
| HFM1 | 1:91260766 | −2.04 | 0.042 |
| NCOA1 | 2:24491914 | 4.34 | 1.50x10−5 |
| LRRC3B | 3:26622806 | −0.11 | 0.91 |
| SPOCK3 | 4:166733384 | 1.45 | 0.15 |
| ANXA10 | 4:168092515 | 1.62 | 0.11 |
| TREM2 | 6:41158506 | 3.71 | 2.00x10−4 |
| ZNF890P | 7:5121239 | −2.32 | 0.020 |
| BZW2 | 7:16646131 | −5.36 | 8.30x10−8 |
| NFX1 | 9:33290511 | −0.76 | 0.45 |
| AQP7 | 9:33383179 | 0.24 | 0.81 |
| CALCB | 11:14904997 | −4.20 | 2.70x10−5 |
| INSC | 11:15112424 | 0.14 | 0.89 |
| SLC43A3 | 11:57406954 | 6.79 | 1.20x10−11 |
| CNTN5 | 11:99020953 | −3.88 | 1.00x10−4 |
| PPM1H | 12:62643982 | −3.99 | 6.70x10−5 |
| AVPR1A | 12:63142759 | 1.88 | 0.060 |
| DOCK9 | 13:98793429 | 1.94 | 0.052 |
| PIEZO2 | 18:10666483 | 4.63 | 3.70x10−6 |
| TRAPPC8 | 18:31829173 | −0.66 | 0.51 |
| APOE | 19:44908684 | 2.06 | 0.039 |
| DMWD | 19:44905754 | −0.26 | 0.80 |
Chr: chromosome; Pos: start position.
*
significance threshold P=0.0022