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. 2023 Nov 30;14:7659. doi: 10.1038/s41467-023-43132-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Association of cell-type-specific ADPRSs with cortical Aβ (florbetapir PET cortical composite SUVR). b Association of cell-type-specific ADPRSs with temporal lobe tau (flortaucipir PET temporal lobe composite SUVR). c Association of cell-type-specific ADPRSs with hippocampal volume (HV). d Association of cell-type-specific ADPRSs with screening Preclinical Alzheimer Cognitive Composite (PACC). The y-axis indicates -log₁₀(p-value) of each association. The black solid horizontal line indicates the p-value corresponding to statistical significance (FDR = 0.025), and the black dashed horizontal line indicates p = 0.05. The p-values (two-sided, unadjusted) are from linear regression models adjusting for APOE ε4, APOE ε2, age, sex, intracranial volume (only for c), years of education (only for d), and the first three genotyping principal components. Effect size of each statistically significant PRS-trait association was quantified with ΔR² (difference of adjusted R2 between the linear models with and without the given PRS term) and indicated above the bar graph. Also, see Supplementary Tables 18, 22, 25, and 26 for further details. Source data are provided as a Source Data file. Created with Biorender.com. SUVR standardized uptake value ratio.