Table 1.

Characterization of CD8 T-cell subsets.

Subset	Surface markers	Cytokine requirements	Effector cytokines	Transcription factors
Tc1 cells	CD49d	IL-2, IL-12	Perforin, granzyme B, IFN-γ, TNF-α	STAT4, T-bet, EOMES
Tc2 cells	CysLT1, BLT-1	IL-4	IL-4, IL-5, IL-13	STAT6, GATA3
Tc9 cells	IL-9R	IL-4, TGF-β	IL-9, IFN-γ	STAT6, IRF4
Tc17 cells	CD161, CD26, CD6, CD39, CD69, CD120b and PD-1	IL-6, TGF-β, IL-1β, IL-21, IL-23	IL-17, IL-22, GM-CSF	STAT3, RORγt
Tc22 cells	IL-6R	IL-6, IL-21, TNF-α	IL-22, IL-17	AhR, STAT1, STAT3, STAT5
Tfcs	CXCR5	IL-6, IL-21, IL-23, TGF-β	IL-4, IL-21, IFN-γ	TCF-1, BCL-6, E2a, Runx3
Qa1-restricted CD8+ Tregs	CD122, Ly49	IL-15	TGF-β, perforin	Eomes
Foxp3+ CD8+ Tregs	CD103	TGF-β	IL-10, TGF-β	FOXP3