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. 2023 Nov 9;55(11):2320–2331. doi: 10.1038/s12276-023-01118-6

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Fig. 2 — a RLRs are activated by RNA derived from a virus or bacteria and mediate the production of type I and III IFNs and inflammatory cytokines via the MAVS adaptor protein. Interferons released into the extracellular compartment activate interferon-stimulated genes and induce direct antiviral responses. b Positive regulation of RLRs by posttranslational modifications and interacting proteins. c Negative regulation of RLRs by posttranslational modifications and interacting proteins.