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. 2023 Nov 9;55(11):2320–2331. doi: 10.1038/s12276-023-01118-6

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Fig. 3 — a cGAS and IFI16, as major DNA receptors in the cytoplasm, induce STING-dependent inflammatory cytokines and IFN production and inhibit viral replication by activating interferon-stimulated genes. b Posttranslational modifications of amino acid residues at different sites regulate the activity of cGAS and nuclear localization of IFI16; a variety of proteins have been shown to participate in regulating the activity of cGAS.