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Pathogenic RFC1 motifs are predicted to form G-quadruplexes
| Gene: analysed sequences | QGRS-Mapper score |
G4Hunter score |
|---|---|---|
| RFC1: (AGGGC)10 | 42 | 1.83 |
| RFC1: (AAGGG)10 | 42 | 2.00 |
| RFC1: (AAGGC)10 | 21 | 1.82 |
| RFC1: (AAAGG)10 | 21 | 0.94 |
| RFC1: (AGAGG)10 | 21 | 1.12 |
| RFC1: (AAAAG)10 | No putative G4 identified | |
| c-MYC: TGGGGAGGTGGGGAGGGTGGGGAAGG | 41 | 2.59 |
| HRAS-1: TCGGGTTGCGGCGCAGGCACGGGCG | 41 | 1.19 |
G-score values comparison between repeat configurations found in RFC1 and well-known G4-forming sequences.
