Table 1.

Demographic and clinical features of control subjects and Alzheimer’s patients

	Control subjects	Alzheimer’s disease subjects	P-value
n	69	64	–
Age, years	71.4 (7.9)	74.8 (7.3)	0.007**
Female, n (%)	42 (61)	34 (53)	0.367
ApoE4, n (%)	16 (24)	33 (58)	<0.001***
Education, years	11.3 (5.4)	7.6 (3.9)	<0.001***
BMI	25.2 (3.7)	24.7 (3.7)	0.750
Dementia score
MMSE	29.0 (1.2)	19.8 (5.8)	<0.001***

Demographic and clinical features of control subjects (n = 69) and Alzheimer’s patients (n = 64), P-values were calculated using unpaired, two-tailed Student’s t-test for continuous Gaussian variables (or Mann-Whitney test for non-Gaussian variables) and chi-square test for categorical data. There were eight missing values for ApoE4, six missing values for MMSE and BMI. Alzheimer’s patients were significantly older (**P = 0.007), showed a significant increase in the prevalence of ApoE4 carriers (***P < 0.001), were less educated (***P < 0.001) and had lower MMSE score (***P < 0.001) than cognitively healthy controls. Except for values on females and ApoE4, data are presented as means + SEM. A greater proportion of patients with Alzheimer’s disease presented with higher incidence of hypercholesterolemia and vascular diseases and were medicated with antidepressant/anxiolytic drugs than healthy controls (Supplementary material, Extended Table 8). BMI = body mass index; MMSE = Mini-Mental State Examination.