Table 2.
Demographic information of human donors
| Donor | Sex | APOE | Age | E | BMI | MMSE | CDR |
|---|---|---|---|---|---|---|---|
| Control_1 | M | ε3ε3 | 80 | 5 | 24.6 | 26 | 0 |
| Control_2 | F | ε3ε4 | 71 | 5 | 25.6 | 29 | 0 |
| Control_3 | M | ε3ε3 | 67 | 13 | 24.7 | 27 | 0 |
| Control_4 | M | ε3ε3 | 68 | 19 | 25.1 | 30 | 0 |
| AD_1 | M | ε3ε4 | 74 | 8 | 24.9 | 12 | 2 |
| AD_2 | F | ε3ε3 | 78 | 8 | 23.1 | 24 | 1 |
| AD_3 | F | ε3ε4 | 77 | 5 | 34.2 | 20 | 3 |
| AD_4 | F | ε3ε3 | 80 | 5 | 23.8 | 19 | 1 |
Donor metadata: demographic and clinical characteristics of human donors (n = 4) used for rat colonization. MMSE and CDR scores were used to determine cognitive function applicable to dementia of human donors. Cognitive function was significantly impaired in human Alzheimer’s donors compared to control donors as measured by MMSE, unpaired, two-tailed Student’s t-test, *P = 0.0131 and CDR scores, Mann-Whitney test, *P = 0.0286. Human donors in both groups displayed no significant difference in age, unpaired, two-tailed Student’s t-test, P = 0.8326; education level, Mann-Whitney test, P = 0.6571 and BMI, Mann-Whitney test, P = 0.6857. BMI = body mass index; CDR = Clinical Dementia Rating; E = Education; MMSE = Mini-Mental State Examination.