Figure 7.

PPAB001 treatment promotes macrophage infiltration of 4T-1 tumors

(A) Representative F4/80 staining tumor images with hIgG, anti-CD24, CV1-hFc, and PPAB001 treatment (magnification ×20). (B) IHC analysis of tumor infiltrating F4/80⁺ cell counts. (C) The level of IL-6 in serum from tumor-bearing mice treated with different agents was measured by ELISA kit. Data are shown as means ± SEMs (n = 6). (D) The level of TNF-α in serum from tumor-bearing mice treated with different treatments was measured by ELISA kit. Data are shown as means ± SEMs (n = 6), and statistical significance was determined by a Student’s t test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.