Table 3.
Longitudinal analysis of rating tools dataa
| Rating tool | XPA | XPC | XPD | XPE | XPG | XPV | Global χ2 test | Statistically significant pairwise contrasts |
|---|---|---|---|---|---|---|---|---|
| SARA total | 0.63 (0.38, 0.89) | −0.03 (−0.26, 0.19) | 0.91 (0.61, 1.21) | 0.05 (−0.52, 0.62) | 0.54 (−0.07, 1.15) | 0.07 (−0.29, 0.43) | 32.37, df = 5, P < 0.001 | D versus C, V A versus C |
| ADL total | 0.42 (0.16, 0.67) | −0.01 (−0.22, 0.21) | 0.55 (0.19, 0.92) | 0.07 (−0.51, 0.65) | 0.36 (−0.32, 1.04) | 0.16 (−0.28, 0.60) | 10.39, df = 5, P = 0.065 | Non-significant (D versus C, P = 0.097; A versus C, P = 0.131) |
| INAS total | 0.19 (0.04, 0.34) | −0.02 (−0.14, 0.11) | 0.36 (0.19, 0.52) | 0.14 (−0.21, 0.49) | −0.18 (−0.51, 0.14) | 0.03 (−0.20, 0.26) | 17.66, df = 5, P = 0.003 | D versus C, G |
ADL = Activities of Daily Living questionnaire; INAS = Inventory of Non-Ataxia Signs; SARA = Scale for the Assessment and Rating of Ataxia.
aResults represent estimated mean progression rates (points per year), as a function of follow-up time, for each total score in each complementation group (accounting for intrasubject variability), with their 95% CIs. χ2 values represent the test for global differences among progression rates in the groups. If such test is significant (P < 0.05), pairwise contrasts are calculated and corrected for multiple comparisons via the Tukey’s method. Statistically significant contrasts for each total score (P < 0.05) are summarized in the last column.