Table 4.
Estimated mean frequencies of INAS items in the different complementation groupsa
| INAS item | XPA | XPC | XPD | XPE | XPG | XPV | Statistically significant contrasts (95% credible intervals) |
|---|---|---|---|---|---|---|---|
| UL hyporeflexia | 54.3 | 5.7 | 74.2 | 15.4 | 30.2 | 23.4 | D versus C, E, G, V A versus C, E, V G versus C |
| LL hyporeflexia | 47.5 | 3.4 | 85.8 | 12.4 | 34.3 | 53.2 | D versus A, C, E, G, V V versus C, E A versus C G versus C |
| Hypopallesthaesia | 16.7 | 3.5 | 37.1 | 12.1 | 7.5 | 17.4 | D versus C, G A versus C |
| UL hyperreflexia | 2.0 | 9.6 | 0.2 | 0.0 | 22.7 | 0.0 | G versus A, D, E, V C versus D, V |
| LL hyperreflexia | 3.1 | 14.1 | 11.3 | 0.0 | 41.4 | 0.2 | G versus A, D, E, V |
| Babinski sign | 10.6 | 0.6 | 25.8 | 0.0 | 56.2 | 0.1 | G versus A, C, E, V D versus C, E, V A versus C |
| LL spasticity | 20.7 | 7.4 | 28.3 | 0.0 | 30.7 | 0.1 | G versus C, E, V D versus C, E, V A versus E, V |
| Distal UL paresis | 9.9 | 0.7 | 13.8 | 0.0 | 27.6 | 20.3 | G versus C, E V versus C, E D versus C A versus C |
| Distal LL paresis | 12.8 | 0.3 | 24.8 | 0.0 | 29.8 | 3.5 | G versus C, E, V D versus C, E, V A versus C, E |
| Bulbar atrophy | 4.0 | 0.5 | 2.6 | 0.0 | 21.2 | 3.8 | G versus C, E |
| Distal UL atrophy | 7.0 | 0.8 | 9.1 | 0.0 | 17.1 | 6.8 | G versus C |
| Distal LL atrophy | 11.8 | 0.5 | 20.1 | 0.0 | 28.5 | 6.7 | G versus C, E D versus C, E A versus C, E |
| Craniocervical chorea | 3.2 | 0.4 | 11.2 | 0.0 | 32.8 | 0.0 | G versus A, C, E, V D versus C, E, V |
| UL chorea | 5.8 | 0.4 | 23.1 | 0.0 | 34.7 | 0.0 | G versus A, C, E, V D versus A, C, E, V |
| Craniocervical dystonia | 9.5 | 0.3 | 7.0 | 0.0 | 31.4 | 0.0 | G versus A, C, D, E, V A versus C, E, V D versus C |
| UL dystonia | 13.3 | 8.7 | 22.7 | 5.4 | 20.9 | 0.0 | G versus V D versus V A versus V |
| Axial myoclonus | 1.2 | 0.2 | 0.1 | 18.3 | 6.2 | 2.6 | E versus A, C, D |
| Altered ocular pursuit | 34.3 | 1.7 | 49.8 | 0.0 | 46.0 | 18.4 | D versus C, E, V G versus C, E A versus C, E, V versus C, E |
| Hypometric saccades | 25.5 | 7.9 | 40.8 | 0.0 | 48.8 | 16.4 | G versus C, E D versus C, E A versus C, E V versus E |
| Horizontal ophthalmoparesis | 9.3 | 1.0 | 23.0 | 0.0 | 0.1 | 0.1 | D versus C, E, G, V |
| Vertical ophthalmoparesis | 27.8 | 1.8 | 31.9 | 0.0 | 32.2 | 7.7 | G versus C, E D versus C, E A versus C, E |
| Slowness of saccades | 21.2 | 4.1 | 36.9 | 0.0 | 26.7 | 0.0 | D versus C, E, V G versus C, E, V A versus C, E, V |
| Urinary dysfunction | 17.2 | 8.5 | 27.2 | 0.0 | 38.1 | 12.7 | G versus C, E D versus E |
| Cognitive impairment | 58.4 | 17.6 | 85.0 | 15.1 | 83.2 | 4.3 | D versus C, E, V G versus C, E, V A versus C, E, V |
INAS = Inventory of Non-Ataxia Signs; LL = lower limb; UL = upper limb.
aData for all the INAS items can be found in Supplementary Table 12. Frequencies are presented as percentages. Frequencies were calculated using Bayesian methods to account for intrasubject variability.