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. 2023 Aug 28;146(12):5070–5085. doi: 10.1093/brain/awad249

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oligodendrocyte subpopulations appear stable at P9 in Δ10 homozygous mice. We probed for Pdgfrα (A and B) and Ng2 (C and D) protein expression in YFP+ cells at P9 in +/Δ10s (A and C) and Δ10/Δ10s (B and D). Cells co-expressing YFP and Pdgfrα or Ng2 appeared to be slightly more numerous in Δ10 heterozygotes relative to homozygotes. Inset pictures display hindbrain (pontomedullary), corpus callosum (splenium and genu), striatum and cerebellar arbor vitae. Δ10/Δ10 = tamoxifen-treated transgenic mice carrying a Pdgfrα-CreERT allele and homozygous Polr3b^fl alleles; +/Δ10 = tamoxifen-treated transgenic mice carrying a Pdgfrα-CreERT allele and heterozygous Polr3b^fl alleles; CTRL = tamoxifen-treated transgenic mice carrying no Pdgfrα-CreERT allele(s); C. callosum = corpus callosum; YFP = yellow fluorescent protein; Pdgfrα = platelet-derived growth factor receptor alpha.