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. 2023 Sep 13;22(12):1422–1433. doi: 10.1158/1535-7163.MCT-23-0251

Figure 2.

Figure 2. KPT9274 and KRASG12C inhibitors show synergistic effects on the inhibition of cell proliferation in vitro. Different dose combinations of KPT9274 with MRTX849 (A and C) and AMG510 (B and D) synergistically inhibit the proliferation of KRASG12C-mutant PDAC cell line MIA PaCa-2 and NSCLC cell line NCI-H358, as indicated by combination index (CI) values less than 1. Cell viability was determined by MTT assay and synergy analysis was performed by using CalcuSyn software. All results are expressed as percentage of control ± SEM of six replicates.

KPT9274 and KRASG12C inhibitors show synergistic effects on the inhibition of cell proliferation in vitro. Different dose combinations of KPT9274 with MRTX849 (A and C) and AMG510 (B and D) synergistically inhibit the proliferation of KRASG12C-mutant PDAC cell line MIA PaCa-2 and NSCLC cell line NCI-H358, as indicated by combination index (CI) values less than 1. Cell viability was determined by MTT assay and synergy analysis was performed by using CalcuSyn software. All results are expressed as percentage of control ± SEM of six replicates.