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. 2023 Dec;64(12):1858–1864. doi: 10.2967/jnumed.123.265935

FIGURE 2.

FIGURE 2.

Immuno-PET imaging of inflammatory cytokines in IBD. (A) Immuno-PET imaging of TNF-α in colitis mice. Shown are representative PET images of control, DSS-treated, and blocked DSS-treated mice at different time points after injection of [89Zr]Zr-DFO-infliximab. Tracer clearly delineated inflamed colon as early as 2 h after injection. (Reprinted with permission of (14).) (B) [89Zr]Zr-a-IL-1β PET imaging of colonic inflammation. Shown are representative PET images of DSS and healthy mice acquired 24 h after injection of tracer. (Reprinted from (5).) (C) Immuno-PET/CT imaging of IL-12/23p40 in healthy and DSS-treated mice. Shown are representative PET/CT (maximum-intensity projection) images of healthy and colitis mice acquired at 24 and 48 h after injection of [89Zr]Zr-DFO-anti-IL-12/23p40. Tracer clearly delineated intestinal inflammation. (Reprinted from (34).) Li = liver.