Description and functions of the significant proteins uniquely identified in the down-regulated proteins of CM change to up-regulated proteins of RM, this information was obtained from the UniProtKB database.

Accession	Protein name	Biological process
O09167 RL21_MOUSE	60S ribosomal protein L21	Component of the large ribosomal subunit for the synthesis of proteins in the cell
O35593 PSDE_MOUSE	26S proteasome non-ATPase regulatory subunit 14	Maintains protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions; therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair
P47911 RL6_MOUSE	60S ribosomal protein L6	Component of the large ribosomal subunit to synthesize proteins in the cell
Q922R8 PDIA6_MOUSE	Protein disulfide-isomerase A6	May function as a chaperone inhibiting aggregation of misfolded proteins, plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin
Q99J47 DRS7B_MOUSE	Dehydrogenase/reductase SDR family member 7B	Putative oxidoreductase