Figure 2.
Spatial overlap between whole-brain Network Based Statistic (NBS) network and D2/3 receptor density in cocaine use disorder (CUD). A) Visualization of the total (positive and negative) number of significant edges at each region within the NBS component (Fig. 1B + 1D) where change in fcMRI was significantly correlated with the spatial D2/3 receptor density in a discovery sample (Sandiego 2015, pspin=0.019) and two replication samples (Jaworska 2020, pspin=0.030 and Smith 2017, pspin=0.013), respectively). B) D2/3 binding potential of PET samples for each receptor source, i.e., discovery sample and replication samples. Color scale normalized between −1.0 to 1.0 for cortex and subcortex separately. C) Each violin-box plot contains (from left to right) distribution of 10k spin-test null correlations between each edge of the NBS component and the spatial density of D2/3 receptors. Red dot indicates significant spearman’s correlation. * reflects statistical significance at the threshold pspin<0.05. Discovery Sample: Sandiego et al., (2015) (12); Replication 1: Jaworska et al., 2020 (13); Replication 2: Smith et al., 2017 (14).