Table 1. Summary of survival cassette designs used in K562 armoring tests.
Schematic description of gene-coding sequences inserted between lentiviral packaging elements of host transfer plasmid. All cassettes were placed under a constitutive MNDU3 promoter.
| Name | Cassette configuration |
|---|---|
| Survival1 | BCL2-P2A-XIAP-T2A-MCL1 |
| Survival2 | XIAP-P2A-BCL2-IRES(VCIP)-tCD34-T2A-MCL1 |
| Survival3 | XIAP-P2A-BCL2-IRES(ECMV)-tCD34-T2A-MCL1 |