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[Preprint]. 2024 Aug 18:2023.11.21.563853. Originally published 2023 Nov 21. [Version 3] doi: 10.1101/2023.11.21.563853

Figure 2. KV1.8−/− type I hair cells had much longer membrane charging times and higher input resistances (voltage gains) than KV1.8+/+,+/− type I HCs.

Figure 2.

(A) gK,L strongly affects passive membrane properties: (A.1) Vrest, (A.2) Rin, input resistance, and (A.3) membrane time constant, τRC = (Rinput * Cm). See Table 2 for statistics. (B) Current clamp responses to the same scale from (B.1) KV1.8+/− and (B.2) KV1.8−/− type I cells, both P29. Filled arrowhead (B.2), sag indicating IH activation. Open arrowhead, Depolarization rapidly decays as IDR activates. B.3, The 1st 6 ms of voltage responses to 170-pA injection is normalized to steady-state value; overlaid curves are double-exponential fits (KV1.8+/+, τ 40 μs and 2.4 ms) and single-exponential fits (KV1.8−/−, τ 1.1 ms).