Figure 7. A K_V7-selective blocker, XE991, reduced residual delayed rectifier currents in K_V1.8^−/− type I and II HCs.

(A) XE991 (10 μM) partly blocked similar delayed rectifier currents in type I and type II K_V1.8^−/− HCs and a type II K_V1.8^+/+ HC.

(B) Properties of XE991-sensitive conductance, g_DR(K_V7). (B.1) % Block of steady-state current. (B.2) tail G-V curves for K_V1.8^−/− type I HCs (n=8), K_V1.8^−/− type II HCs (9), and K_V1.8^+/+ type II HCs (5); mean ± SEM. (B.3) V_half was less negative in K_V1.8^+/+ type II than K_V1.8^−/− type I HC (p = 0.01, KWA). (B.4) Conductance density was similar in all groups (ANOVA, non-significant at 40% power (left), 20% power (right).