Table 3.
Type II hair cell KV currents: Activation and inactivation time course at +30 mV. Mean ± SEM. g is effect size, Hedge’s g. KWA is Kruskal-Wallis ANOVA.
| Zone | Kv1.8 | τAct at 30 mV, msa, b | τInact,Fast at 30 mV, msc, d | Fast inactivation prominencee | Inactivation %f, g | N cells | Age (median, range) |
|---|---|---|---|---|---|---|---|
| LES | +/+ | 2.11 ± 0.09 | 23 ± 3 | 0.46 ± 0.03 | 45 ± 2 | 30 | 46, 14–312 |
| +/− | 1.64 ± 0.09 | 15 ± 2 | 0.53 ± 0.03 | 51 ± 2 | 27 | 29, 13–280 | |
| −/− | 4.4 ± 0.5 | NA | NA | 25 ± 3 | 21 | 128, 15–355 | |
| MES | +/+ | 2.8 ± 0.5 | 50 ± 10 | 0.40 ± 0.04 | 42 ± 3 | 9 | 94, 22–296 |
| +/− | 2.2 ± 0.2 | 90 ± 60 | 0.42 ± 0.03 | 47 ± 2 | 15 | 24, 13–52 | |
| −/− | 10 ± 7 | NA | NA | 29 ± 5 | 10 | 84, 28–355 | |
| Striola | +/+ | 2.7 ± 0.3 | 50 ± 10 | 0.31 ± 0.07 | 39 ± 3 | 5 | 45, 40–287 |
| +/− | 2.9 ± 0.4 | 300 ± 200 | 0.3 ± 0.06 | 28 ± 2 | 5 | 19, 14–30 | |
| −/− | 7 ± 2 | NA | NA | 22 ± 2 | 6 | 202, 29–298 |
a
−/− vs +/+: KWA, p = 0.0048, g 0.6; −/− vs +/−: KWA, p = 2.3E-7, g 0.6
b
Striola vs LES: KWA, p = 5.7E-4, g 1.0
c
+/− vs +/+: KWA, p = 0.027, g 0.2
d
LES vs MES: KWA, p = 0.0018, g 0.3; LES vs Striola: KWA, p = 1.9E-4, g 0.8
e
LES vs Striola: 2-way ANOVA, p = 0.0041, g 0.7
f
−/− vs +/+: 2-way ANOVA, p < 1E-9, g 1.7; −/− vs +/−: 2-way ANOVA, p < 1E-9, g 1.8
g
Striola vs LES: 2-way ANOVA, p = 3.4E-5, g 0.9; Striola vs MES: 2-way ANOVA, p = 0.0011, g 1.0; Interaction between genotype and Zone: 2-way ANOVA, p = 0.026