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SasG-I blocks adhesion of SasG-II, and likewise SasG-II can block adhesion of SasG-I, indicating they can all bind the same corneocyte receptor in some capacity. However, removal of N-glycans and core 1 or 3 O-glycans does not block SasG-II binding as it does with SasG-I, suggesting that SasG-II may bind a core 2 O-glycan structure elsewhere on the corneocyte receptor.
