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[Preprint]. 2024 Sep 4:2023.11.14.567139. [Version 7] doi: 10.1101/2023.11.14.567139

PMC10690195.4; 2023 Nov 21
PMC10690195.5; 2023 Dec 17
PMC10690195.6; 2024 Apr 22
PMC10690195.7; 2024 Sep 4

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Figure 3. — Chromosomal analyses for disease genes. (A) The proportions of disease genes across chromosomes. The pink bars represent the autosomes, while green and blue indicate the X and Y chromosomes, respectively. The proportions (%) for different chromosomes are shown above bars. (B) The linear regression plotting of disease gene counts against the numbers of total genes with age information on chromosomes. (C) Numbers of genes related to the abnormality of non-genitourinary system (non-reproductive system) are plotted against all protein-coding genes on chromosomes with gene age information. (D) Numbers of genes related to the abnormality of genitourinary system (the reproductive system) are plotted against all protein-coding genes on chromosomes with gene age information. (E) Linear regression of dated disease gene counts against the total numbers of genes on chromosomes for female-specific reproductive disease genes with gene age information. (F) Linear regression of disease gene counts against the total numbers of genes on chromosomes for male-specific reproductive disease genes with gene age information. The autosomal linear models are displayed on the top left corner. Note: All linear regression formulas and statistics pertain only to autosomes. “A”, “X”, and “Y” indicate autosomes, X and Y chromosomes, respectively.