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Single-cell measurement of mRNA copy-number. (a) Single-molecule fluorescence in situ hybridization (smFISH) is used to detect mRNA molecules in individual E. coli cells. (b) The measured distribution of mRNA copy number deviates from Poisson statistics but is well described by a two-state model. Image and data are reproduced from (Wang et al., 2022) with permission from the Royal Society of Chemistry.
