Extended Data Fig. 7: Epistatic genes non-uniformly reshape cardiomyocyte size distributions.

a, A heatmap of relative differences of cell sizes at various quantile levels between gene-silencing and scramble control conditions for unaffected and MYH7-R403Q variant cardiomyocytes. Larger quantiles correspond to larger cells in the cell size distribution. Dark red indicates strong reduction of cell sizes at the specified quantile level in gene-silenced cells relative to the scramble control. The corresponding statistical differences (b) were evaluated by the maximum p-values across all batches of cells using a bootstrap quantile test (with 10,000 bootstrapped samples). c, Representative QQ-plots of cell size quantiles comparing between gene-silenced cells and scramble controls for both unaffected (top row) and MYH7-R403Q variant (bottom row) cardiomyocytes indicate a clear size-bias in the effect of silencing CCDC141-IGF1R on correcting cardiomyocyte hypertrophy.