Table 1 —
Demographic, clinical, and biomarker data of the Mayo and ADNI cohorts
| Mayo cohort | ||||
|---|---|---|---|---|
|
| ||||
| ADNC | ADNC/LATE-NC | LATE-NC | P | |
|
| ||||
| n | 75 | 81 | 9 | - |
| Age at first visit | 74.2 [63.7, 80.5] | 79 [72.2, 83.9] | 86.2 [83.6, 93.3] | < 0.001 |
| Age at death | 82.4 [71.1, 88.3] | 89.1 [83.9, 92.4] | 91.6 [88.7, 95.5] | < 0.001 |
| Sex (F, M) | 33, 42 | 36, 45 | 4, 5 | 0.8 |
| Education | 16 [12,18] | 16 [12, 17] | 14 [13, 16] | 0.38 |
| CDR-SB | 1.5 [0.5, 3.5] | 1.5 [0.5, 3] | 0.5 [0.5, 1.25] | 0.39 |
| AD dementia | 27 | 30 | 1 | - |
| Amnestic MCI | 48 | 51 | 8 | - |
| APOE4 (+, −) | 47, 27 | 55, 24 | 1, 7 | 0.006 |
| Amyloid-PET centiloid | 110 [87.3, 129] | 110 [76.7, 122] | 9.75 [7.60, 13.4] | < 0.001 |
| AV1451 SUVR | 1.85 [1.72, 2.28] | 2.14 [1.40, 2.36] | 1.26* | - |
|
| ||||
| ADNI cohort | ||||
|
| ||||
| ADNC | ADNC/LATE-NC | LATE-NC | P | |
|
| ||||
| n | 26 | 19 | 8 | - |
| Age at first visit | 75.8 [70.3, 81.1] | 77.7 [72.2, 85.5] | 74.9 [72.6, 81.7] | 0.4 |
| Age at death | 79 [76.2, 85.8] | 84 [79, 89] | 80.5 [79.8, 87] | 0.17 |
| Sex (F, M) | 9, 17 | 5, 14 | 1, 7 | 0.5 |
| Education | 16 [16, 18] | 16 [13.5, 17] | 16 [14.5, 18] | 0.28 |
| CDR-SB | 2 [1, 3.38] | 3.5 [2, 4.5] | 1 [0.875, 1.12] | 0.019 |
| AD dementia | 9 | 11 | 0 | - |
| Amnestic MCI | 17 | 8 | 8 | - |
| APOE4 (+, −) | 20, 6 | 13, 6 | 1, 7 | 0.004 |
| Amyloid-PET centiloid | 69.5 [50.2, 110] | 91 [81, 102] | −5 [−11.8, 0] | 0.0015 |
| AV1451 SUVR | NA | 1.52 [1.49, 1.55] | 1.08* | - |
*
One observation only. Values are expressed as counts or median and interquartile ranges. CDR-SB = Clinical Dementia Rating scale - Sum of Boxes; ADNC = Alzheimer’s disease neuropathological changes; LATE-NC = Limbic-predominant age-related TDP-43 encephalopathy neuropathological changes; MCI = Mild cognitive impairment; PET = Positron emission tomography; SUVR = Standard uptake value ratio.